Professor Paul-Alain Jaffrès

Université de Brest, France

CEMCA-UMR CNRS 6521
COSM Research group
e-mail: pjaffres@univ-brest.fr

Web links:
UMR CNRS 6521: http://www.umr6521.cnrs.fr/
COSM Group: http://www.univ-brest.fr/cosm
Chemistry department: http://www.univ-brest.fr/departement-chimie
SynNanoVect Platform: http://www.univ-brest.fr/synnanovect

Key words: Phosphorus chemistry, amphiphilic compounds, hybrid materials,

Career
– 1-9-2006 Professor – University of Brest.
– 2004-2005 Research sabbatical year funded by CNRS – Utrecht University, Pr. G. van Koten.
– 07-2003 Habilitation.
– 1-9-1998 Lecturer – University of Caen.
– 1997-1998 Post-doc: St Andrews University (Scotland), Pr. R. E. Morris.
– 1996 PhD Thesis – LCMT – Caen. Promotor Pr. D. Villemin.

Teaching (192h/year)
– Lecture, 1st year – atomistic.
– Lecture, 1st year medical studies. General chemistry.
– Lecture, 2nd year Chemistry – Organic chemistry.
– Lecture, 1st Year Master, Organic chemistry.
– Practical works, 1st Year Master, Organic chemistry.
– Lecture, 2nd Year Master, Organic chemistry.

Research
Research funding (selection since 2015): IBSAM (2020-2021, coordination); ANR (CosyCell, 2019-2023, participant); SATT Grand Ouest (2018, Patent valorization, Scientific coordinatation); Regional and La Ligue co-funding for a PdD thesis (Alicia Baudin 2017-2020, Promotor) ; ANR (HYMN, 2014-2018, Local coordinator); La Ligue contre le cancer (2016, local coordinator) ; Vaincre la Mucoviscidose (VLM ; 2018-2019, local coordinator); Vaincre la Mucoviscidose (VLM ; 2017-2018, local coordinator).

Student supervision
PhD thesis: 9 ; Master/DEA : 28

Scientific collaborations
UMR INSERM 1078 (Brest – Pr. T. Montier ; Pr. G. Le Gac) ; UMR INSERM 1227 (Brest – Dr. O.
Migen) ; UMR UPR CNRS 4301 (Orléans – Dr. P. Midoux) ; UMR INSERM 991 (Rennes – Dr. P.
Loyer) ; UMR CNRS 6226 (Rennes – Pr. T Benvegnu) ; UMR INSERM 1069 (Tours – Pr. C. Vandier) ; UMR CNRS 5248 (Bordeaux – Pr. E. Dufourc) ; University of Wolverhampton – UK (Dr. G. Hix) ; University of Utrecht – Pays-Bas (Pr. G. Van Koten) ; Pr. C.V. Stevens (Ghent University)

Scientific production
Publications: 137 ; Proceeding in international journals: 34 Book chapters: 3
Patent: 3
Google scoolar : https://scholar.google.com/citations?user=lSnd2SEAAAAJ&hl=fr

Conferences and invited lectures
Research conferences: 21 ; Conferences for general public: 17

Member of Jury
PhD thesis: 42 ; Habilitation (HDR): 10.

Valorization of research
Member of the Platform SynNanoVect. Certified ISO9001 since 2013.

Reviewing
– Reviewing for different editors: ACS, Beilstein, Elsevier, RSC, Wiley-VCH.

Pedagogic and administrative responsibilities
– Since 2017 : Animator of the team « Chimie Organique, Santé, Matériaux » COSM
– Head of the group « Phosphore & Vectorisation” of the CEMCA Lab (2007-2016)
– Master 1 jury president (2007-2013)
– Elected at the board of the Faculty of Sciences (2011-2015) and since 2020.
– Since 2015- Member of the scientific board of ISBAM (Institut Brestois en Santé Agro Matière).
– 2016-2020 – Elected at the board of the University of Brest.

Direction
– 2013-2019 Director of the chemistry department – Department including 40 permanent members (researcher/teacher, technician).
– Since 03/2020 : Director of the scientific board of IBSAM (Institut Brestois Santé-Agro- Matière). Institut constituted by 9 laboratories and 2 platforms (200 researchers and 65 technicians).

Selection of publications (since 2019)
Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect.
C. M. Sevrain, D. Fontaine, A. Bauduin, M. Guéguinou, B.L. Zhang, A. Chantôme, K. Mahéo, C. Pasqualin, V. Maupoil, H. Couthon, C. Vandier, P.A. Jaffrès
Org. Biomol. Chem., 2021, 19, 2753-2766.

Development of pyrene-based Fluorescent ether lipid as inhibitor of SK3 ion channels.
A. Bauduin, M. Papin, A. Chantôme, H. Couthon, L. Deschamps, J. Requejo-Isidro, C. Vandier, P.A. Jaffrès
Eur. J. Med. Chem., 2021, 209, 112894

M(H2O)(PO3C10H6OH).(H2O)0.5 (M=Co, Mn, Zn, Cu) : a new series of layered metallophosphonate compounds obtained from 6-hydroxy-2-naphthylphosphonic acid
F. Beaubras, J.M. Rueff, O. Perez, F. Veillon, V. Caignaert, J.F. Lohier, J. Cardin, G. Rogez, C. Jestin, H. Couthon, P.A. Jaffrès
Dalton Trans., 2020, 49, 3877-3891

Cationic amphiphiles producing hexagonal aggregates: Physico-chemical characterization and application to gene delivery.
A. Bouraoui, R. Ghanem, M. Berchel, L. Deschamps, V. Vié, G. Paboeuf, T. Le Gall, T. Montier, P.A. Jaffrès
Org. Biomol. Chem., 2020, 18, 337-345

Designing of a magnetoelectric system in hybrid organic-inorganic framework, a perovskite layered phosphonate MnO3PC6H4-m-Br.H2O
T. Basu, C. Bloyet, F. Beaubras, V. Caignaert, O. Perez, J.M. Rueff, A. Pautrat, B. Raveau, J.F. Lohier,
P.A. Jaffrès, H. Couthon, G. Rogez, G. Taupier, H. Dorkenoo
Adv. Funct. Mater., 2019, 1901878

Bis-thioether containing lipid chains in cationic amphiphiles: physicochemical properties and application for gene delivery
A. Bouraoui, R. Ghanem, M. Berchel, V. Vié, Y. Le Guen, G. Paboeuf, L. Deschamps, T. Le Gall, T. Montier, P.A. Jaffrès
ChemPhysChem, 2019, 20, 2187-2194

Thiol-ene click reaction to construct the lipid chains of cationic amphiphiles: physico-chemical behaviour and application for gene delivery
A. Bouraoui, M. Berchel, R. Ghanem, V. Vié, G. Paboeuf, L. Deschamps, O. Lozach, T. Le Gall, T. Montier, P.A. Jaffrès
Org. Biomol. Chem, 2019, 17, 3609-3616

Antibacterial and transfection activities of nebulized formulations incorporating long n-alkyl chain silver N-heterocyclic carbene complexes
A. Mottais, M. Berchel, T. Le Gall, Y. Sibiril, F. d’Arbonneau, V. Laurent, P.A. Jaffrès, T. Montier
Inter. J. Pharm., 2019, 567, 118500